Day 1, Thursday, May 14th
08:00–09:15 Re-defining frontline myeloma therapy: The emerging role of BCMA-directed strategies in newly diagnosis multiple myeloma
Pre-COMy CME Symposium
09:15–09:25 COMy 2026 kick-off:
Welcome by the Congress Chairs
09:25–10:40 Session 1: Advances in biology
Moderators: Hervé Avet-Loiseau, France; Rafael Fonseca, USA
09:25–09:40 Genomics: Francesco Maura, USA
09:40–09:55 Microenvironment: Madhav Dhodapkar, USA
09:55–10:10 Role of immune microenvironment in myeloma: Paola Neri, Canada
10:10–10:25 Liquid biopsies: Joaquín Martínez López, Spain
10:25–10:40 Discussion: All session faculty and Gareth Morgan, USA + Mehmet Samur, USA
10:40–11:00 Coffee Break
11:00–12:15 Session 2: New response criteria
Moderators: Rafat Abonour, USA; Heinz Ludwig, Austria
11:00–11:15 Historical perspective: Joan Bladé, Spain
11:15–11:30 Summary of new response criteria: Shaji Kumar, USA
11:30–11:45 Role of MRD: Susan Bal, USA
11:45–12:00 Role of SFL chains and role of urine: Kwee Yong, UK
12:00–12:15 Mass spectrometry: Noemi Puig, Spain
12:15–13:30 Improving the journey: Patient-focused advances with CD38 mAb quadruplet therapy
Industry-supported Symposium
13:30–14:00 Lunch Break
14:00–15:15 Industry-supported Symposium
15:15–16:30 Session 3: Mechanisms of resistance
Moderators: Faith Davies, USA; Marc Raab, Germany
15:15–15:30 Resistance to CAR T: Carlos Fernández de Larrea, Spain
15:30–15:45 Résistance to bispecifics: Hermann Einsele, Germany
15:45–16:00 Resistance to ImiDs: Keith Stewart, Canada
16:00–16:15 Overcoming resistance: Nizar Bahlis, Canada
16:15–16:30 Discussion: All session faculty and Malin Hultcrantz, USA + Michael O’Dwyer, Ireland
16:30–16:50 Coffee Break
16:50–18:05 Session 4: Plenary lectures I
Moderators: Wee Joo Chng, Singapore; Noopur Raje, USA
16:50–17:05 Smoldering multiple myeloma: María-Victoria Mateos, Spain
17:05–17:20 Waldenstrom Disease: Steven Treon, USA
17:20–17:35 Amyloidosis: Suzanne Lentzsch, USA
17:35–17:50 Discussion: All session faculty and Rahul Banerjee, USA + Robert Orlowski, USA
17:50-19:00 Session 5: How to manage high risk disease
Moderators: Meral Beksaç, Turkey; Vania Hungria, Brazil
17:50-18:05 New classification: Jill Corre, France
18:05-18:20 Extra-medullary disease: Saad Usmani, USA
18:20-18:35 Plasma cell leukemia: Cyrille Touzeau, France
18:35-18:50 Functional high-risk: Martin Kaiser, UK
18:50-19:00 Discussion: All session faculty and Luciano Costa, USA + and Rakesh Popat, UK
Day 2, Friday, May 15th
07:00–08:00 Session 6: Webinar showcase from IACH I
Video Session
08:00–09:15 Clinical Application of clonoSEQ Testing in multiple myeloma
Industry-supported Symposium
09:15–10:30 Medical Crossfire: Turning Therapuetic Innovation Into Practice-Personalizing Care in Multiple Myeloma
CME Symposium
10:30–10:50 Coffee Break
10:50–12:05 Session 7: Cure: hope, hype or reality?
Moderators: Irene Ghobrial, USA; Jean-Luc Harousseau, France
10:50–11:05 My definition of cure: Sagar Lonial, USA
11:05–11:20 My definition of cure: Vincent Rajkumar, USA
11:20–11:35 My definition of cure: Jesús San Miguel, Spain
11:35–11:50 Precursor disease and cure: Irene Ghobrial, USA
11:50–12:05 Discussion: All session faculty and Catarina Geraldes, Portugal
12:05–13:20 The red thread of innovation: emerging data and strategies in RRMM treatment
Industry-supported Symposium
13:20–13:50 Lunch Break
13:30-13:45 Session 8: Webinar showcase from IACH II
Video Session during the Lunch Break 
13:50–14:25 Session 9: COMy Awards and lecture series
Chairs: Mohamad Mohty, France; María-Victoria Mateos, Spain; Arnon Nagler, Israel
Awards Presentations Jean-Luc Harousseau Award Multiple Myeloma Pioneers Award Women in Multiple Myeloma Achievement Award
14:25–15:40 Debating the future of RRMM: What is best for our patients?
Industry-supported Symposium
15:40–16:40 Session 10: IMS Session – Multiple myeloma: is cure on the horizon? 
Chairs: Philippe Moreau, France; Nikhil Moreau, USA
16:40-17:55 Unmet Needs in RRMM: Evolving BsAb Therapy From Inpatient to Outpatient Settings
Industry-supported Symposium
17:55-18:15 Coffee Break
18:15–19:45 Session 11: State-of-the-art management
Moderators: Thierry Facon, France; Francesca Gay, Italy
18:15–18:35 Elderly patients: Salomon Manier, France
18:35–18:55 TE patients: Aurore Perrot, France
18:55–19:15 Bone disease: Evangelos Terpos, Greece
19:15-19:30 Thrombosis in myeloma: Uriel Suárez, Spain
19:30-19:45 Discussion: All session faculty and Faisal Basheer, UK + Holly Lee, Canada
19:45–20:15 Session 12: What’s new at aIACH: educational tools for your clinical day-to-day
Day 3, Saturday, May 16th
07:00–08:00 Session 13: Clinical cases
Chairs: Claudio Cerchione, Italy; Nour Moukalled, Lebanon
07:00-07:20 Case discussion 1: Arthur Bobin, France
07:20-07:40 Case discussion 2: thrombosis in myeloma: Emilie Chalayer, France
07:40-08:00 Dicussion: All session faculty and Thomas Chalopin, France + Uriel Suárez, Spain
08:00–09:15 MRD 2.0 : Minimal Invasion, Maximum Insight
Industry-supported Symposium
09:15–10:30 Redefining Myeloma Care: An Expert Roundtable on the Potential of Novel Strategies Across the Disease Spectrum
CME Symposium
10:30–10:50 Coffee Break
10:50–12:00 Session 14: The hard-to-treat-patients
Moderators: Chandramouli Nagarajan, Singapore; Joshua Richter, USA
10:50–11:10 The case for peptide conjugates: Elena Zamagni, Italy
11:10–11:30 NDMM under dialysis: Florent Malard, France
11:30-12:00 Discussion: All session faculty and Doris Hansen, USA + Xavier Leleu, France + Hira Mian, Canada
12:00–13:15 The Evolving Role of ADC-Based BCMA Targeting in RRMM: Evidence-Led Practicalities of Early Intervention
Industry-supported Symposium
13:15–13:45 Lunch Break
13:25-13:40 Session 15: Webinar showcase from IACH III
Video Session
13:45–14:50 Session 16: COMy debates
Moderators: Michel Delforge, Belgium; Thomas Martin, USA
13:45-13:55 1st relapse, the case for CAR T cells: Luciano Costa, USA
13:55-14:05 1st relapse, the case for Ab drug conjugates: Meletios (Thanos) Dimopoulos, Greece
14:05-14:15 Discussion: Debate faculty and Roman Hajek, Czech Republic + Andrzej Jakubowiak, USA
14:15-14:25 Doublet maintenance: Paul Richardson, USA
14:25-14:35 Single agent maintenance: Pieter Sonneveld, Netherlands
14:35-14:50 Discussion: Debate faculty and Hartmut Goldschmidt, Germany + Andrew Spencer, Australia
14:50–16:05 Advancing RRMM Care With T-cell Redirecting Therapies: Current Landscape and Future Directions
Industry-supported Symposium
16:05–17:20 Beyond Head-to-Head Trials: Answering Real Myeloma Questions – What Matching-Adjusted Indirect Comparisons (MAICs) Show and What They Don’t
Industry-supported Symposium
17:20–17:30 Coffee Break
17:30–19:30 Session 17: Plenary lectures II
Moderators: Jesús Berdeja, USA; Joy Ho, Australia
17:30-18:00 35 years of myeloma trials: Philippe Moreau, France
18:00-18:30 Genomics guiding therapy: Nikhil Munshi, USA
18:30-19:00 The future of multiple myeloma therapy: Kenneth Anderson, USA
19:00-19:30 Discussion: All session faculty and Mohamad Mohty, France + Arnon Nagler, Israel
19:30–20:00 Session 18: COMy in-person conclusions
Day 4, Sunday, May 17th – ONLINE ONLY
10:00-11:05 Multiple Myeloma Communications I
Moderators: Mohamad Mohty, France; María-Victoria Mateos, Spain; Arnon Nagler, Israel
10:00-10:10 Daratumumab (Dara) Monotherapy vs. Active Monitoring (ActMon) in Patients with High-Risk Smoldering Myeloma (SMM): AQUILA Outcomes based on Mayo 2018/IMWG 2020 Risk Stratification, IMWG 2020 plus Cytogenetic Criteria, and Age:
Philippe Moreau, France
10:10-10:20 ARLOCABTAGENE AUTOLEUCEL (ARLO-CEL) IN PATIENTS WITH HEAVILY PRETREATED RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): FINAL ANALYSIS FROM THE PHASE 1 STUDY:
Susan Bal, USA
10:20-10:30 Effectiveness of bridging therapy corresponds to improved outcomes after ciltacabtagene autoleucel (cilta-cel): phase 3 CARTITUDE-4 study of patients with relapsed, lenalidomide-refractory multiple myeloma:
Xavier Leleu, France
10:30-10:40 BELANTAMAB MAFODOTIN, BORTEZOMIB, AND DEXAMETHASONE (BVd) VS DARATUMUMAB, BORTEZOMIB, AND DEXAMETHASOME (DVd) IN RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): LONG-TERM RESPONDER ANALYSIS OF THE PHASE 3 DREAMM-7 TRIAL:
Vania Hungria, Braziil
10:40-10:50 SUBGROUP ANALYSIS OF DREAMM-7 AND DREAMM-8: OUTCOMES WITH BELANTAMAB MAFODOTIN (BELAMAF) IN PATIENTS WITH FUNCTIONAL HIGH-RISK (FHR) RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM):
María-Victoria Matoes, Spain
10:50-11:05 Discussion
11:05-11:15 Break
11:15-12:20 Multiple Myeloma Communications II
Moderators: Mohamad Mohty, France; María-Victoria Mateos, Spain; Arnon Nagler, Israel
11:15-11:25 Isatuximab in Combination with Lenalidomide and Dexamethasome (Isa-Rd) in Patients with High-Risk Smoldering Multiple Myeloma (HR-SMM): Phase 3 ITHACA Study Final Safety Run-in (SRI) Results:
María-Victoria Mateos, Spain
11:25-11:35 Safety Results from REALiTEC Cohort 2: A Multi-Country Observational Study of Teclistamab in Relapsed/Refractory Multiple Myeloma in Real World:
TBA
11:35-11:45 BELANTAMAB MAFODOTIN (BELMAF) IN COMBINATION WITH BORTEZOMIB, LENALIDOMIDE, AND DEXAMETHASONE (VRD) FOR PATIENTS (PTS) WITH TRANSPLANT-INELIGIBLE (TI) NEWLY DIAGNOSED MULTIPLE MYELOMA (NDMM): A FOCUS ON TREATMENT EFFICACY AND MANAGEMENT/RESOLUTION OF OCULAR EVENTS IN THE PHASE 1 DREAMM-9 STUDY:
Saad Usmani, USA
11:45-11:55 COMPARATIVE EFFICACY OF LINVOSELTAMAB VERSUS IDECABTAGENE VICLEUCEL (IDE-CEL) AND CILTACABTAGENE AUTOLEUCEL (CILTA-CEL) IN TRIPLE-CLASS EXPOSED (TCE) RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): A MATCHING-ADJUSTED INDIRECT COMPARISON (MAIC):
Joshua Richter, USA
11:55-12:05 PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM) WHO ACHIEVED SUSTAINED MINIMAL RESIDUAL DISEASE-NEGATIVITY WITH BELANTAMAB MAFODOTIN (BELAMAF) TREATMENT IN DREAMM-7:
María-Victoria Mateos, Spain
12:05-12:20 Discussion
12:20-12:30 Conclusion and see you next year!